Isolation and structures of mono- and di-deacetyl chromomycin antibiotics 02-3D and 02-3G from Streptomyces avellaneus.

UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties.

Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifungal activities of UK-2 compounds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.

Isolation and characterization of a phage active against streptomyces griseus

Isolation and Identification of Streptomyces ramulosus from Soil and Determination of Antimicrobial Property of its Pigment

Background and objective: Pigment production by microorganisms is important due to more rapid growth, higher efficiency, easier extraction, and antimicrobial effects compared to other methods. The aim of the present study is to isolate and identify antibiotic pigment-producing actinomycetes from the soil of the Persian Gulf and to evaluate the antibiotic activity of their pigments in the second...

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities.

A new inhibitor of protein kinase C (PKC), UCN-01, was isolated from the culture broth of Streptomyces sp. N-126. We have found that this strain also produces UCN-02 which is a stereoisomer of UCN-01. The inhibitors have the molecular formula C28H26N4O4 and have an indolo[2,3-alpha]carbazole chromophore. Their structures have been elucidated by mass and NMR spectra. UCN-01 has been shown to inh...

Isolation of ASR7 Actinomycete Isolated from S12 Demospongia Marine Sponge and Study of Its Antibacterial Activity

Background and Aims: Marine Actinomycetes are gram-positive bacteria that sometimes are free, saprophytic or plant and animal-associated, including marine sponges. More than 75% of antibiotics and antimicrobial compounds are produced by actinomycetes. In recent years, due to the need for new drugs, marine microorganisms have been considered as new sources of potential production of significant ...